Two people were taken to AHN Forbes Hospital in Monroeville on Wednesday after a four-vehicle crash on Route 30 in Hempfield, according to Mutual Aid spokesperson Shawn Penzera.
Their conditions were unclear.
Traffic was affected more than two hours. The eastbound side of the highway was shut down in the area of the Cedar Street exit.
The crash was reported just before 5:15 p.m. and traffic was diverted onto Route 119 and other side streets.
The road remained closed until about 7:30 p.m.
State police are investigating.