Part of Route 40 was closed in Fayette County on Monday evening after a crash that killed three people, according to state police.

Trooper Kalee Barnhart confirmed the fatalities and said the crash involved a tractor-trailer and two passenger vehicles.

The wreck was reported around 6 p.m. near Youghiogheny River Lake in Henry Clay Township. The road was closed in both directions in the area of Laurel Road, police said.

Route 40, also known as National Pike, has seen numerous fatalities in Fayette County in recent years from crashes.

Two were killed and seven injured in September 2023 in a two-vehicle crash in Wharton Township, west of Monday’s scene. That crash happened when one vehicle crossed the center line, slamming head-on into the second vehicle.

Five people were killed in March 2024 in a three-vehicle crash on Route 40 in the same area as the 2023 crash. Investigators determined a driver that crossed the center line and slammed into a tractor-trailer had cocaine in his system.