Saturday's contest between the St. Louis Cardinals (23-26) and the Chicago Cubs (27-24) at Busch Stadium should be a tight matchup, as our computer prediction projects a final score of 6-5, with the Cardinals taking home the win. Game time is at 7:15 PM ET on May 25.

The Cubs will give the ball to Jameson Taillon (3-2, 2.20 ERA), who is eyeing win No. 4 on the season, and the Cardinals will counter with Miles Mikolas (3-5, 5.77 ERA).

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Cubs vs. Cardinals Game Info & Odds

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Cubs vs. Cardinals Score Prediction

  • Our pick for this game is Cardinals 6, Cubs 5.

Total Prediction for Cubs vs. Cardinals

  • Total Prediction: Over 7.5 runs

Cubs Performance Insights

  • The Cubs have played as the favorite in four of their past 10 games and won one of those contests.
  • In its last 10 games with a total, Chicago and its opponents have failed to hit the over seven times.
  • The Cubs have been favorites in 18 games this season and won nine (50%) of those contests.
  • Chicago has entered five games this season favored by -150 or more, and won each of those games.
  • The moneyline for this contest implies a 60% chance of a victory for the Cubs.
  • Chicago has scored the 17th-most runs in the majors this season with 218 (4.3 per game).
  • The Cubs have the 11th-ranked team ERA among all MLB pitching staffs (3.73).

Cardinals Performance Insights

  • In five games as the underdog over the last 10 matchups, the Cardinals have a record of 3-2.
  • In its last 10 games with an over/under, St. Louis and its opponents have combined to eclipse the total eight times.
  • The Cardinals have won in 10, or 43.5%, of the 23 contests they have been named as odds-on underdogs this year.
  • This year, St. Louis has won three of eight games when listed as at least +125 or worse on the moneyline.
  • The Cardinals have an implied victory probability of 44.4% according to the moneyline set for this matchup.
  • St. Louis scores the second-fewest runs in baseball (189 total, 3.9 per game).
  • Cardinals pitchers have a combined ERA of 4.26 ERA this year, which ranks 21st in MLB.

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Cubs Schedule

Date Opponent Score Pitching Matchup
May 18 Pirates W 1-0 Shota Imanaga vs Bailey Falter
May 19 Pirates L 3-2 Jameson Taillon vs Mitch Keller
May 21 Braves W 4-3 Javier Assad vs Charlie Morton
May 22 Braves L 9-2 Justin Steele vs Max Fried
May 23 Braves L 3-0 Ben Brown vs AJ Smith-Shawver
May 25 @ Cardinals - Jameson Taillon vs Miles Mikolas
May 26 @ Cardinals - Javier Assad vs Sonny Gray
May 27 @ Brewers - Javier Assad vs Robert Gasser
May 28 @ Brewers - Justin Steele vs Freddy Peralta
May 29 @ Brewers - Shota Imanaga vs Bryse Wilson
May 30 @ Brewers - Jameson Taillon vs Colin Rea

Cardinals Schedule

Date Opponent Score Pitching Matchup
May 18 Red Sox W 7-2 Miles Mikolas vs Kutter Crawford
May 19 Red Sox L 11-3 Matthew Liberatore vs Nick Pivetta
May 20 Orioles W 6-3 Sonny Gray vs Dean Kremer
May 22 Orioles W 3-1 Lance Lynn vs Kyle Bradish
May 22 Orioles W 5-4 Kyle Gibson vs John Means
May 25 Cubs - Miles Mikolas vs Jameson Taillon
May 26 Cubs - Sonny Gray vs Javier Assad
May 27 @ Reds - Lance Lynn vs Nick Martínez
May 28 @ Reds - Kyle Gibson vs Frankie Montás
May 29 @ Reds - Miles Mikolas vs Graham Ashcraft
May 31 @ Phillies - TBA vs TBA

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dataskrive is a Tribune-Review freelancer. You can contact dataskrive at info@triblive.com.